Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. Cytogenetic analysis, fluorescent in situ hybridisation FISH , and molecular amplification have been used to characterise the transfer of Yp fragments to Xp Support Center Support Center. Mapping the testis determinants by an analysis of Y-specific sequences in males with apparent XX and XO karyotypes and females with XY karyotypes. Population structure of the human pseudoautosomal boundary. Prenatal cytogenetic and postnatal molecular studies on 46,XX male. Genetic evidence equating SRY and the testis-determining factor.