The x-axis represents MM, and the y-axis represents GS. Browse "Advance Publication" version. How to face it for therapeutic approaches. We found that the age-related DEGs in the green module were significantly enriched in B cell activation and receptor signaling pathways and other immunity-related signaling pathways, thereby revealing a close relationship between aging and immune system function. A total of age-related DEGs belonged to the interactive set, and longevity-related DEGs were allocated to the complement set of longevity and control groups. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and protein—protein interaction pathway analyses were conducted on these 46 DEGs, which are mainly enriched in B cell activation and receptor signaling pathways. Age-related key genes are highly interactive and play a central role in the progress of biological aging.