Another choice is a botanical massage oil called Zestra. Psychosocial issues and female sexuality. Low sex drive can be very difficult for you and your partner. Request an Appointment at Mayo Clinic. Male hormones, such as testosterone, also play an important role in female sexual function, even though testosterone occurs in much lower amounts in women. Recommendations may include sex education, counseling, and sometimes medication and hormone therapy. Drinking alcohol or taking fluconazole Diflucan , a common medication to treat vaginal yeast infections, can make these side effects worse. For example, antidepressants such as paroxetine Paxil and fluoxetine Prozac, Sarafem may lower sex drive.